PXD036900-2

PXD036900 is an original dataset announced via ProteomeXchange.

Title	Biomarkers found in the tumor interstitial fluid may help explain the differential behavior among keratinocyte carcinomas
Description	Keratinocyte carcinomas (KC) are the most common malignancy worldwide. This category of tumours groups both basal (BCC) and squamous (SCC) cell carcinomas. While the former rarely metastasizes (0.03-0.55%), the latter is more associated to a substantial risk of local recurrence, metastasis and death (1.5-4%). In addition, it is well known that the extracellular signals from tumour cells are involved in most of the steps triggering metastasis. This pro-metastatic signalling is mediated by proteins secreted by cancer cells, which constitute the tumour secretome and can be obtained from tumour interstitial fluid (TIF). The TIF baths the tumour and stromal cells and characterizes the tumour microenvironment. The proteomic study of TIF is of particular interest for explaining the metastatic potential of a tumour. In this work, we have analysed the proteomic composition of the TIF from BCC and SCC tumour biopsies and discovered a new set of extracellular proteins that could be useful as differential biomarkers. In addition, these proteins may help to understand the distinct invasive and metastatic abilities of the KC.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:58:51.939.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joan Josep Bech-Serra
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-21 09:38:40	ID requested
1	2023-04-14 06:21:20	announced
⏵ 2	2023-11-14 08:58:52	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: orbitrap dusion lumos,basal cell carcinoma, squamous cell carcinoma, tumor interstitial fluid, label free

Eloi Gari
contact affiliation	Cell Cycle, Department of Basic Medical Sciences, Institut de Recerca Biomèdica de Lleida (IRBLLEIDA), University of Lleida, Lleida, Spain.
contact email	eloi.gari@udl.cat
lab head
Joan Josep Bech-Serra
contact affiliation	Proteomics Unit - Josep Carreras Leukaemia Research Institute
contact email	jbech@carrerasresearch.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD036900

PRIDE project URI

• PRIDE
  1. PXD036900
     1. Label: PRIDE project
     2. Name: Biomarkers found in the tumor interstitial fluid may help explain the differential behavior among keratinocyte carcinomas