PXD036867 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Quantitative proteomic profiling of anti-androgenic sexual endocrine perturbation in zebrafish embryos |
Description | Endocrine disruption (ED) can trigger far-reaching effects on environmental populations, justifying a refusal of market approval for chemicals with ED properties. For the assessment of ED effects on development and reproduction, regulatory decisions mostly rely on apical endpoints from in vivo testing with adult animals. Here, we present a rapid and reproducible data dependent proteomics approach for identifying comprehensive molecular fingerprints interfering with the sexual endocrine system in zebrafish (Danio rerio) embryos as an alternative to animal testing. For this, we have analysed flutamide as model substances for anti-androgenic perturbation in a modified zebrafish embryo toxicity test (zFET). These signatures allow for a definition of solid biomarkers as tools in screening approaches and for integration in chronic toxicity studies for identifying suspect ED substances, in the fish early life-stage test (OECD TG 210). |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:31:19.840.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Steve Ayobahan |
SpeciesList | scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: 7955; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-09-20 14:54:40 | ID requested | |
1 | 2023-02-25 01:02:30 | announced | |
⏵ 2 | 2023-11-14 08:31:23 | announced | 2023-11-14: Updated project metadata. |
Publication List
Ayobahan SU, Alvincz J, Reinwald H, Strompen J, Salinas G, Sch, รค, fers C, Eilebrecht E, Eilebrecht S, Comprehensive identification of gene expression fingerprints and biomarkers of sexual endocrine disruption in zebrafish embryo. Ecotoxicol Environ Saf, 250():114514(2023) [pubmed] |
Keyword List
submitter keyword: Zebrafish embryos, Endocrine disruptors, LC-MS/MS |
Contact List
Dr. Sebastian Eilebrecht |
contact affiliation | Fraunhofer Institute for Molecular Biology and Applied Ecology IME Auf dem Aberg 1 | 57392 Schmallenberg | Germany |
contact email | sebastian.eilebrecht@ime.fraunhofer.de |
lab head | |
Steve Ayobahan |
contact affiliation | Fraunhofer IME |
contact email | steve.ayobahan@ime.fraunhofer.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD036867
- Label: PRIDE project
- Name: Quantitative proteomic profiling of anti-androgenic sexual endocrine perturbation in zebrafish embryos