PXD036740 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Immunotherapeutic antibodies derived from human tumor tertiary lymphoid structures |
| Description | We report that intratumoral Tertiary Lymphoid Structures (TLS) in human ovarian cancer contain highly oligoclonal B cells that produce IgA and IgG. Using a recombinant antibody cloned from the dominant sequence of an ovarian cancer TLS, we abrogated the growth of the autologous human tumor in vivo, through recognition of the extracellular domain of tumor-promoting GPR85. TLS-derived antibodies therefore contribute to anti-tumor immunity, which could be leveraged for novel immunotherapies. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-12 |
| AnnouncementXML | Submission_2026-06-11_18:00:37.969.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD036740 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | John Koomen |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-09-14 14:18:03 | ID requested | |
| ⏵ 1 | 2026-06-11 18:00:38 | announced | |
Publication List
Keyword List
| submitter keyword: Ovarian Cancer, Target Identification,Antibodies, Tertiary Lymphoid Structures |
Contact List
| Jose Conejo-Garcia |
|---|
| contact affiliation | Department of Integrated Immunobiology
Duke School of Medicine
Durham, NC, USA |
| contact email | jose.conejo-garcia@duke.edu |
| lab head | |
| John Koomen |
|---|
| contact affiliation | Moffitt Cancer Center |
| contact email | john.koomen@moffitt.org |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD036740 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD036740
- Label: PRIDE project
- Name: Immunotherapeutic antibodies derived from human tumor tertiary lymphoid structures
