PXD036644-1

PXD036644 is an original dataset announced via ProteomeXchange.

Title	Targeting kinome reprogramming in ESR1 fusion-driven breast cancer
Description	Multiplexed, deep-scale LC-MSMS analysis for proteome and phosphoproteome expression profile and the targeted LC-MSMS analysis for kinases in enriched kinome of the ER+ breast cancer patient-derived xenograft tumors.
HostingRepository	PRIDE
AnnounceDate	2023-10-24
AnnouncementXML	Submission_2023-10-24_15:02:16.964.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	MeggieYoung
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; phosphorylated residue; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-12 05:37:01	ID requested
⏵ 1	2023-10-24 15:02:17	announced
2	2023-11-14 09:12:40	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:13:17	announced	2024-10-22: Updated project metadata.

Gou X, Kim BJ, Anurag M, Lei JT, Young MN, Holt MV, Fandino D, Vollert CT, Singh P, Alzubi MA, Malovannaya A, Dobrolecki LE, Lewis MT, Li S, Foulds CE, Ellis MJ, Kinome Reprogramming Is a Targetable Vulnerability in ESR1 Fusion-Driven Breast Cancer. Cancer Res, 83(19):3237-3251(2023) [pubmed]

ProteomeXchange project tag: Human Proteome Project, CPTAC Consortium

submitter keyword: LC-MSMS,ESR1 fusion, Breast Cancer, Breast Cancer Patient-Derived Xenograft (PDX) Tumor, Proteome, Phosphoproteome

Charles E.Foulds
contact affiliation	Charles E. Foulds, Ph.D. Assistant Professor Lester and Sue Smith Breast Center Baylor College of Medicine
contact email	foulds@bcm.edu
lab head
MeggieYoung
contact affiliation	Baylor College of Medicine
contact email	meggie.young@bcm.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD036644

PRIDE project URI

• PRIDE
  1. PXD036644
     1. Label: PRIDE project
     2. Name: Targeting kinome reprogramming in ESR1 fusion-driven breast cancer