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PXD036604 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteogenomic Landscape and Clinical Characterization of GH-Producing Pituitary Adenoma
DescriptionGene alteration analysis on 121 GH-producing pituitary adenomas and non-target proteomics analysis with RNA sequencing analysis on 45 non-functioning pituitary adenomas (NFPAs) and 60 growth hormone (GH)-producing pituitary adenomas were performed, and integrated these results with the clinical characteristics of acromegaly. We attempted to identify key players involved in shaping the clinical features of acromegaly, especially those related to treatment efficacy. This project revealed the importance of GNAS mutations in terms of clinical and biochemical characteristics and identified novel molecules that may be involved in the responsiveness to medical treatment.
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYusuke Kawashima
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListS-carboxamidomethyl-L-cysteine; unknown modification
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-09 21:58:48ID requested
12022-11-23 22:47:14announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: pituitary tumor, pituitary neuroendocrine tumor (PitNET), acromegaly, growth hormone producing adenoma
Contact List
Tomoaki Tanaka
lab head
Yusuke Kawashima
contact affiliationKazusa DNA Research Institute
dataset submitter
Full Dataset Link List
jPOST dataset URI
Dataset FTP location
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