PXD036547-1

PXD036547 is an original dataset announced via ProteomeXchange.

Title	Activity-dependent regulation of SLK phosphorylation
Description	Maintaining an appropriate balance between excitation and inhibition is critical for information processing in cortical neurons. It is known that cortical neurons receive widely disparate levels of excitation. To ensure efficient coding, they are capable of cell-autonomously adjusting the inhibition they receive to the individual levels of excitatory input, but the underlying mechanisms are not understood. The article associated with this data shows that Ste20-like kinase (SLK) in cortical neurons mediates cell-autonomous regulation of excitation-inhibition balance in the thalamocortical feed-forward circuit, but not in the feed-back circuit. The parallel reaction monitoring data here supports the link between activity, SLK phosphorylation and function.
HostingRepository	PanoramaPublic
AnnounceDate	2022-10-24
AnnouncementXML	Submission_2022-10-24_22:17:28.113.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Mark Graham
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	Phospho; Carbamidomethyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-09-05 22:33:09	ID requested
⏵ 1	2022-10-24 22:17:28	announced

Dataset with its publication pending

submitter keyword: parallel reaction monitoring, Ste20-like kinase, neurons

Mark Graham
contact affiliation	Children's Medical Research Institute
contact email	mgraham@cmri.org.au
lab head
Mark Graham
contact affiliation	Children's Medical Research Institute
contact email	mgraham@cmri.org.au
dataset submitter

Panorama Public dataset URI