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PXD036547 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleActivity-dependent regulation of SLK phosphorylation
DescriptionMaintaining an appropriate balance between excitation and inhibition is critical for information processing in cortical neurons. It is known that cortical neurons receive widely disparate levels of excitation. To ensure efficient coding, they are capable of cell-autonomously adjusting the inhibition they receive to the individual levels of excitatory input, but the underlying mechanisms are not understood. The article associated with this data shows that Ste20-like kinase (SLK) in cortical neurons mediates cell-autonomous regulation of excitation-inhibition balance in the thalamocortical feed-forward circuit, but not in the feed-back circuit. The parallel reaction monitoring data here supports the link between activity, SLK phosphorylation and function.
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMark Graham
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListPhospho; Carbamidomethyl
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-09-05 22:33:09ID requested
12022-10-24 22:17:28announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: parallel reaction monitoring, Ste20-like kinase, neurons
Contact List
Mark Graham
contact affiliationChildren's Medical Research Institute
contact emailmgraham@cmri.org.au
lab head
Mark Graham
contact affiliationChildren's Medical Research Institute
contact emailmgraham@cmri.org.au
dataset submitter
Full Dataset Link List
Panorama Public dataset URI