PXD036413 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Dysregulation of Wnt/β-Catenin Signaling pathway via RNF146 upregulation in the prefrontal cortex is responsible for social deficit in a VPA-induced ASD mouse model |
Description | Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder where patients have impaired social behavior, communication, repetitive behaviors, and restricted interest. Valproic acid (VPA) has been widely used to treat patients with epilepsy and bipolar disorder patients. However, VPA treatment during pregnancy has produced offspring with neurodevelopmental disorders, including ASD. To better understand the molecular function of ASD, we have used valproic acid, chemically induced ASD mice. We have performed LC-MS/MS analysis of VPA-induced offspring mice to the control to see the difference in their proteome difference. Our analysis showed that many neuronal network pathways were highly expressed in our differentially expressed proteins, and among them, Wnt/ β-catenin pathways showed clear enrichment. The RNF146 (E3 Ubiquitin-protein ligase) increase in VPA-exposed mice showed a highly significant effect on canonical Wnt/ β-catenin signaling pathways by disrupting the β-catenin destruction complex. The proteins like CREBBP, TCF4, and GSK3B also showed significant changes that indicate dysfunction of β-catenin destruction complex and activation of transcription factors. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_06:40:26.807.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD036413 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Wooyoung Jang |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-08-30 14:27:32 | ID requested | |
1 | 2023-07-24 01:18:51 | announced | |
⏵ 2 | 2023-11-14 06:40:27 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: mouse model, Valproic acid, VPA, Wnt signaling, Rnf146,Autism spectrum disorder, beta-catenin |
Contact List
Min-Sik Kim |
contact affiliation | Professor at Daegu Gyeongbuk Science & Technology (DGIST), New Biology Department. |
contact email | mkim@dgist.ac.kr |
lab head | |
Wooyoung Jang |
contact affiliation | kyung hee university |
contact email | jangwooyoung92@khu.ac.kr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD036413
- Label: PRIDE project
- Name: Dysregulation of Wnt/β-Catenin Signaling pathway via RNF146 upregulation in the prefrontal cortex is responsible for social deficit in a VPA-induced ASD mouse model