PXD036366-1

PXD036366 is an original dataset announced via ProteomeXchange.

Title	CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology
Description	Interleukin-17A (IL-17A) is a key mediator of protective immunity to yeast and bacterial infections but also drives the pathogenesis of several autoimmune diseases, such as psoriasis or psoriatic arthritis. Here, we show that the tetra-transmembrane protein CMTM4 is a subunit of the IL-17 receptor (IL-17R). CMTM4 constitutively associated with IL-17R subunit C (IL-17RC) to mediate its stability, posttranslational modification, and plasma membrane localization. Both mouse and human cell lines deficient in CMTM4 were largely unresponsive to IL-17A, due to their inability to assemble the IL-17 receptor signaling complex. Accordingly, CMTM4-deficient mice were largely resistant to experimental psoriasis. Collectively, our data identified CMTM4 as an essential component of the IL-17 receptor and a potential therapeutic target for treating IL-17-mediated autoimmune diseases.
HostingRepository	PRIDE
AnnounceDate	2022-12-02
AnnouncementXML	Submission_2022-12-02_09:27:42.741.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	PeterDraber
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	methylthiolated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-28 03:25:19	ID requested
⏵ 1	2022-12-02 09:27:43	announced
2	2023-11-14 08:58:52	announced	2023-11-14: Updated project metadata.

submitter keyword: CMTM4, IL-17 receptor signaling complex, IL-17A, IL-17RC

PeterDraber
contact affiliation	Laboratory of Immunity & Cell Communication, BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic
contact email	peter.draber@lf1.cuni.cz
lab head
PeterDraber
contact affiliation	BIOCEV, First Faculty of Medicine, Charles University
contact email	peter.draber@lf1.cuni.cz
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD036366
     1. Label: PRIDE project
     2. Name: CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology