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PXD036366 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology
DescriptionInterleukin-17A (IL-17A) is a key mediator of protective immunity to yeast and bacterial infections but also drives the pathogenesis of several autoimmune diseases, such as psoriasis or psoriatic arthritis. Here, we show that the tetra-transmembrane protein CMTM4 is a subunit of the IL-17 receptor (IL-17R). CMTM4 constitutively associated with IL-17R subunit C (IL-17RC) to mediate its stability, posttranslational modification, and plasma membrane localization. Both mouse and human cell lines deficient in CMTM4 were largely unresponsive to IL-17A, due to their inability to assemble the IL-17 receptor signaling complex. Accordingly, CMTM4-deficient mice were largely resistant to experimental psoriasis. Collectively, our data identified CMTM4 as an essential component of the IL-17 receptor and a potential therapeutic target for treating IL-17-mediated autoimmune diseases.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPeter Draber
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListmethylthiolated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-08-28 03:25:19ID requested
12022-12-02 09:27:43announced
22023-11-14 08:58:52announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: CMTM4, IL-17 receptor signaling complex, IL-17A, IL-17RC
Contact List
Peter Draber
contact affiliationLaboratory of Immunity & Cell Communication, BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic
contact emailpeter.draber@lf1.cuni.cz
lab head
Peter Draber
contact affiliationBIOCEV, First Faculty of Medicine, Charles University
contact emailpeter.draber@lf1.cuni.cz
dataset submitter
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Dataset FTP location
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