PXD036318-1

PXD036318 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Quantification of mature lamin A and progerin in HGPS patient cells
Description	The ratio of progerin to mature lamin A correlates with disease severity in HGPS patients, and can be used to assess the effectiveness of therapies aimed at lessening aberrant splicing and/or progerin farnesylation. We have developed the first non-immunological method, based on a targeted MS approach and the use of isotope-labelled internal standards, that reliably quantifies the levels of wild-type lamin A and farnesylated progerin in cells from HGPS patients.
HostingRepository	jPOST
AnnounceDate	2023-08-26
AnnouncementXML	Submission_2023-08-25_08:00:15.313.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Emilio Camafeita
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	unknown modification
Instrument	LTQ Orbitrap; LTQ Orbitrap Elite

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-26 06:17:26	ID requested
⏵ 1	2023-08-25 08:00:15	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: Hutchinson-Gilford progeria syndrome
progerin
farnesylation
mass spectrometry
targeted proteomics
precursor-reaction monitoring

submitter keyword: Hutchinson-Gilford progeria syndrome

progerin

farnesylation

mass spectrometry

targeted proteomics

precursor-reaction monitoring

Contact List

Jesús Vázquez
lab head
Emilio Camafeita
contact affiliation	CNIC
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST001825/