PXD036079-1

PXD036079 is an original dataset announced via ProteomeXchange.

Title	Identification and Validation of microparticle proteins as biomarkers for diabetic retinopathy
Description	Diabetic retinopathy (DR) is a microvascular complication that develops in diabetic individuals. There are currently no methods to detect the onset or progression of DR. Biomarkers can help identify the subset of diabetics who are at high risk of developing DR or those DR patients with a high probability to progress quickly to advanced stage. In this study, we examined the serum microparticles as a source of biomarkers for DR. We profiled the microparticle proteome and compared across six different sample groups representing the onset and progression of DR. We found that the microparticle proteins participate in DR pathogenesis. We also validated eight of these proteins and found two to be biomarkers for DR.
HostingRepository	PRIDE
AnnounceDate	2025-01-17
AnnouncementXML	Submission_2025-01-17_00:04:21.482.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD036079
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jeya Maheshwari Jayapal
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-16 08:28:11	ID requested
⏵ 1	2025-01-17 00:04:21	announced

10.6019/PXD036079;

submitter keyword: Diabetic retinopathy, microparticles, serum, biomarkers

Jeya Maheshwari Jayapal
contact affiliation	Proteomics Department, Aravind Medical Research Foundation
contact email	jm.jeya@gmail.com
lab head
Jeya Maheshwari Jayapal
contact affiliation	Aravind Medical Research Foundation
contact email	jm.jeya@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD036079
     1. Label: PRIDE project
     2. Name: Identification and Validation of microparticle proteins as biomarkers for diabetic retinopathy