PXD035947-1

PXD035947 is an original dataset announced via ProteomeXchange.

Title	The acetyltransferase chameau (chm) functions as metabolic sensor in regulating energy homeostasis and starvation response in Drosophila melanogaster
Description	The coupling of metabolism to the posttranslational modification of proteins has been suggested to play an important role in the modulation of protein function in response to physiological variation. This interplay could potentially establish feedback loops that buffer extreme environmental challenges. Protein acetylation is one such posttranslational protein modification that is tightly coupled to metabolic variation. Here, we show that the acetyltransferase chameau (chm), which affects life span in Drosophila, is also involved in the regulation of metabolism upon environmental cues. While chm haploinsufficiency increases life span in flies that have sufficient access to nutrients, it reduces their ability to cope with starvation. We hypothesize the starvation susceptibility in mutant flies is caused by their reduced ability to modulate energy homeostasis. Interestingly, this effect is highly dependent on the ambient temperature, suggesting that it evolved to allow organisms to adapt to a wider range of environmental conditions by modulating their energy metabolism.
HostingRepository	PRIDE
AnnounceDate	2023-09-05
AnnouncementXML	Submission_2023-09-05_01:08:56.228.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	IgnasiForne
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	acetylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-10 09:21:47	ID requested
⏵ 1	2023-09-05 01:08:56	announced
2	2023-11-14 07:12:29	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:02:42	announced	2024-10-22: Updated project metadata.

submitter keyword: metabolism,chameau, acetylation, temperature, starvation, HBO1, drosophila

Prof AxelImhof
contact affiliation	Biomedical Center Munich Molecular Biology Großhaderner Strasse 9 82152 Planegg-Martinsried
contact email	aimhof@med.uni-muenchen.de
lab head
IgnasiForne
contact affiliation	Biomedical Center-LMU
contact email	ignasi.forne@lrz.uni-muenchen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/09/PXD035947

PRIDE project URI

• PRIDE
  1. PXD035947
     1. Label: PRIDE project
     2. Name: The acetyltransferase chameau (chm) functions as metabolic sensor in regulating energy homeostasis and starvation response in Drosophila melanogaster