PXD035937-1

PXD035937 is an original dataset announced via ProteomeXchange.

Title	Proteome analysis of AML cells upon CaSR-KO
Description	Haematopoietic stem cells (HSC) reside in locations within the bone marrow microenvironment (BMM) featuring a slightly higher extracellular calcium ion concentration [eCa2+]. HSC respond to [eCa2+] via the G-protein coupled calcium-sensing receptor (CaSR), but the role of CaSR for leukaemia and leukaemia stem cells (LSC), the malignant counterpart to HSC, is poorly defined. Here we performed a proteomic analysis on Lin- MLL AF9+ cells, comparing WT cells to cells lacking CaSR using TMT-based proteomics.
HostingRepository	PRIDE
AnnounceDate	2023-10-24
AnnouncementXML	Submission_2023-10-24_11:05:09.577.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	ChristianMünch
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-10 09:04:38	ID requested
⏵ 1	2023-10-24 11:05:10	announced
2	2023-11-14 09:07:19	announced	2023-11-14: Updated project metadata.
3	2024-10-22 06:08:34	announced	2024-10-22: Updated project metadata.

Pereira RS, Kumar R, Cais A, Paulini L, Kahler A, Bravo J, Minciacchi VR, Krack T, Kowarz E, Zanetti C, Godavarthy PS, Hoeller F, Llavona P, Stark T, Tascher G, Nowak D, Meduri E, Huntly BJP, M, ü, nch C, Pampaloni F, Marschalek R, Krause DS, Distinct and targetable role of calcium-sensing receptor in leukaemia. Nat Commun, 14(1):6242(2023) [pubmed]

submitter keyword: Mouse, TMT, proteome, AML

DanielaKrause
contact affiliation	Goethe-Universität Frankfurt, Georg-Speyer-Haus, Paul-Ehrlich-Str. 42-44, Frankfurt am Main, GERMANY
contact email	Krause@gsh.uni-frankfurt.de
lab head
ChristianMünch
contact affiliation	Goethe University Frankfurt
contact email	ch.muench@em.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/10/PXD035937

PRIDE project URI

• PRIDE
  1. PXD035937
     1. Label: PRIDE project
     2. Name: Proteome analysis of AML cells upon CaSR-KO