PXD035833-2

PXD035833 is an original dataset announced via ProteomeXchange.

Title	Structural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland – lessons from a translational pig model
Description	Growth hormone receptor deficiency (GHRD) results in low serum insulin-like growth factor 1 but high, non-functional GH levels. This study investigates the histomorphological and molecular alterations associated with GHRD. Pituitary glands from 6 months old GHR-KO pigs and control animals were compared using a quantitative stereological approach and label-free proteomics.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:48:07.243.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bachuki Shashikadze
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-07 02:55:27	ID requested
1	2023-05-12 04:07:16	announced
⏵ 2	2023-11-14 08:48:15	announced	2023-11-14: Updated project metadata.

Shashikadze B, Franzmeier S, Hofmann I, Kraetzl M, Flenkenthaler F, Blutke A, Fr, ö, hlich T, Wolf E, Hinrichs A, Structural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland: Lessons from a translational pig model. J Neuroendocrinol, 36(7):e13277(2024) [pubmed]

submitter keyword: proteomics, Brain,Growth hormone receptor deficiency, pig, animal model

Bachuki Shashikadze
contact affiliation	Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
contact email	shashikadze@genzentrum.lmu.de
lab head
Bachuki Shashikadze
contact affiliation	Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany
contact email	shashikadze@genzentrum.lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/05/PXD035833

PRIDE project URI

• PRIDE
  1. PXD035833
     1. Label: PRIDE project
     2. Name: Structural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland – lessons from a translational pig model