PXD035788-1
PXD035788 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Advanced Assesement Through Intact Glycopeptide Analysis of Infliximab Biologics and Biosimilar |
| Description | We demonstrated high-resolution tandem mass spectrometry with an ultra-high-performance liquid chromatography for characterization and comparison between biologics and biosimilar of infliximab at an advanced level. Comparing the N- and O-glycopeptides profiles, a total of 49 and 54 glycopeptides was identified for each product of the biologics and biosimilar, respectively. We also discovered one novel N-glycosylation site at the light chain from both biopharmaceuticals and one novel O-glycopeptide at the heavy chain from only biosimilar. Site-specific glycopeptide analysis process will be a robust and useful technique for evaluating therapeutic mAbs and complex glycoprotein products. |
| HostingRepository | MassIVE |
| AnnounceDate | 2022-11-01 |
| AnnouncementXML | Submission_2022-11-01_06:57:09.477.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Heeyoun Hwang |
| SpeciesList | scientific name: Infliximab; |
| ModificationList | CarbamidomethylDTT |
| Instrument | instrument model |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-08-03 05:35:10 | ID requested | |
| ⏵ 1 | 2022-11-01 06:57:09 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: glycoproteome, infliximab, monoclonal antibody, biopharmaceuticals |
Contact List
| Heeyoun Hwang | |
|---|---|
| contact affiliation | Korea Basic Science Institute |
| contact email | heeyounh@kbsi.re.kr |
| lab head | |
| Heeyoun Hwang | |
| contact affiliation | KBSI |
| contact email | heeyounh@kbsi.re.kr |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000090073/ |
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