⮝ Full datasets listing
PXD035784-1
PXD035784 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | C1Q labels a highly aggressive macrophage-like leukemia population indicating extramedullary infiltration and relapse |
| Description | Extramedullary infiltration (EMI) is a concomitant manifestation indicating poor prognosis of acute myeloid leukemia (AML), yet the underlying mechanism remains poorly understood and therapeutic options are limited. Here, we employed single-cell RNA sequencing on bone marrow (BM) and EMI samples from an AML patient presenting pervasive leukemia cutis. A complement C1Q + macrophage-like leukemia subset which is enriched within cutis and existed in BM prior to EMI manifestations was identified and further verified in multiple AML patients. RNA-sequencing and quantitative proteomics profiling revealed adverse prognosis of patients bearing C1Q + population. C1Q expression endowed leukemia cells with tissue-infiltration ability which could establish prominent cutaneous or gastrointestinal EMI nodules in patient-derived xenograft (PDX) and CDX models. Fibroblasts attracted migration of the C1Q + leukemia cells through surface C1Q-gC1QR recognition and subsequent stimulation of MAFB-TGF-β signaling. Thus, C1Q orchestrates cancer infiltration pathways through communicating with fibroblasts and represents a compelling therapeutic target for EMI. |
| HostingRepository | iProX |
| AnnounceDate | 2022-08-03 |
| AnnouncementXML | Submission_2023-12-06_20:14:52.180.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Li Xia |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-08-02 19:26:48 | ID requested | |
| ⏵ 1 | 2023-12-06 20:14:53 | announced |
Publication List
Keyword List
| submitter keyword: C1Q, CD34+, AML, DIA, Proteome |
Contact List
| Ying Lu | |
|---|---|
| contact affiliation | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine |
| contact email | stove@shsmu.edu.cn |
| lab head | |
| Li Xia | |
| contact affiliation | Shanghai Jiao Tong University School of Medicine |
| contact email | lixia@shsmu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
