PXD035691-1

PXD035691 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomics Reveals the Wolframin-Calcium Axis as a Key Pathogenic Signaling Node in Primary Aldosteronism
Description	Using 4D label-free quantitative proteomics technique, combined with bioinformatics, we generated in-depth proteome and phosphoproteome signaling network maps of aldosterone-producing adenoma and nonfunctioning adrenocortical tumor. We identified wolframin-calcium axis as a key regulatory node in aldosterone synthase activation and aldosterone hypersecretion.
HostingRepository	PRIDE
AnnounceDate	2025-12-26
AnnouncementXML	Submission_2025-12-26_11:24:29.915.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	溢 杨
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	phosphorylated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-01 09:29:58	ID requested
⏵ 1	2025-12-26 11:24:30	announced

10.1161/hypertensionaha.122.20515;

Ma L, Yang S, Yang Y, Chen X, Yang J, He Y, Cheng Q, Li J, Kang B, Tang S, Zhang A, Shu X, Li X, Shen H, Jing Y, Song Y, Li Q, Hu J, Phosphoproteomics Reveals the Wolframin-Calcium Axis as an Important Pathogenic Signaling Node in Primary Aldosteronism. Hypertension, 80(5):995-1010(2023) [pubmed]

submitter keyword: Phosphoproteomics,Primary Aldosteronism,Wolframin

Yang Yi
contact affiliation	the First Affiliated Hospital of Chongqing Medical University
contact email	402535325@qq.com
lab head
溢 杨
contact affiliation	Chongqing medical university
contact email	402535325@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD035691

PRIDE project URI

• PRIDE
  1. PXD035691
     1. Label: PRIDE project
     2. Name: Phosphoproteomics Reveals the Wolframin-Calcium Axis as a Key Pathogenic Signaling Node in Primary Aldosteronism