PXD035679 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival |
Description | Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a plasma membrane proteoglycan, is highly expressed in intestinal subtype gastric tumours and that this signature associates with patients’ poor survival. Further, we mechanistically demonstrate that SDC4 is a master regulator of gastric cancer motility and invasion. We also find that SDC4 conjugated with heparan sulfate chains is efficiently sorted in extracellular vesicles (EVs). Interestingly, SDC4 in EVs regulates gastric cancer cell-derived EV organ distribution, uptake and functional effects in recipient cells. Specifically, we show that SDC4 knockout disrupts the tropism of EVs for the common gastric cancer metastatic sites. Our findings set the basis of the molecular implications of SDC4 expression in gastric cancer cells and open new perspectives on the development of therapeutic strategies targeting the glycan-EV axis to limit tumour progression. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:57:48.235.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD035679 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Hugo Osorio |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-08-01 09:15:44 | ID requested | |
1 | 2023-05-05 06:26:34 | announced | |
⏵ 2 | 2023-11-14 08:57:48 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: extracellular vesicles, extracellular communication, gastric cancer, syndecan-4, heparan sulfate proteoglycans,cancer cell invasion |
Contact List
Ana Magalhaes |
contact affiliation | i3S - Instituto de Investigacao e Inovacao em Saude, Universidade do Porto, Porto, Portugal. IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal. |
contact email | amagalhaes@ipatimup.pt |
lab head | |
Hugo Osorio |
contact affiliation | i3S - Institute for Research and Innovation in Health, University of Porto |
contact email | hosorio@i3s.up.pt |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035679
- Label: PRIDE project
- Name: Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival