PXD035673-2

PXD035673 is an original dataset announced via ProteomeXchange.

Title	Exosome proteomics reveals the deregulation of coagulation, complement and lipid metabolism proteins in gestational diabetes mellitus
Description	Exosomes are the smallest extracellular vesicles which are released during pregnancy by the placenta, umbilical cord, amniotic fluid and various cell membranes in the extracellular space. The content of exosomes during pregnancy is strongly related to various conditions such as gestational diabetes mellitus (GDM). Although it is well-known that GDM is characterized by different levels of chronic low-grade inflammation, complement system dysregulation, vascular dysfunction and platelet activation, there is little data characterizing the serum exosomal protein cargo of GDM patients and their associations to these processes. The aim of this study was to analyze the serum exosomal proteome of GDM patients, with focus on the platelet activation and the complement proteins and their relationship to serum biochemical parameters and other protein markers of lipid metabolism and prothrombotic factors.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:57:47.298.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Felicia Antohe
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2022-08-01 02:42:22	ID requested
1	2022-09-21 23:25:09	announced
⏵ 2	2023-11-14 08:57:47	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: proteomics, lipid metabolism, mass spectrometry, Prothrombotic factors, Complement system,gestational diabetes mellitus, Platelet activation

Felicia Antohe
contact affiliation	Institute of Cellular Biology and Pathology
contact email	felicia.antohe@icbp.ro
lab head
Felicia Antohe
contact affiliation	Institute of Cellular Biology and Pathology "N. Simionescu"
contact email	felicia.antohe@icbp.ro
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/09/PXD035673

PRIDE project URI

• PRIDE
  1. PXD035673
     1. Label: PRIDE project
     2. Name: Exosome proteomics reveals the deregulation of coagulation, complement and lipid metabolism proteins in gestational diabetes mellitus