PXD035611-2

PXD035611 is an original dataset announced via ProteomeXchange.

Title	Chronic exposure to low-level lipopolysaccharide dampens influenza-mediated inflammatory response via A20 and PPAR network
Description	Influenza A virus (IAV) infection leads to severe inflammation, and while epithelial-driven inflammatory responses occur via activation of NF-B, the factors that modulate inflammation, particularly the negative regulators are less well-defined. In this study we show that A20 is a crucial molecular switch that dampens IAV-induced inflammatory responses. Chronic exposure to low-dose LPS environment can restrict this excessive inflammation. The mechanisms that this environment provides to suppress inflammation remain elusive. Here, our evidences show that chronic exposure to low-dose LPS suppressed inflammation in A549 cells induced by IAV infection or LPS stimulationn. Chronic low-dose LPS environment increases A20 expression, which in turn positively regulates PPAR-α and -γ, thus dampens the NF-κB signaling pathway and NLRP3 inflammasome activation. Knockout of A20 abolished the inhibitory effect on inflammation. Thus, A20 and its induced PPAR-α and -γ play a key role in suppressing excessive inflammatory responses in the chronic low-dose LPS environment.
HostingRepository	iProX
AnnounceDate	2022-07-29
AnnouncementXML	Submission_2023-02-06_19:09:42.687.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yinuo Gu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-28 19:42:22	ID requested
1	2022-07-28 19:42:35	announced
⏵ 2	2023-02-06 19:09:43	announced	2023-02-07: Update publication information.

Gu Y, Hsu AC, Zuo X, Guo X, Zhou Z, Jiang S, Ouyang Z, Wang F, A20 and PPAR network. Front Immunol, 14():1119473(2023) [pubmed]

submitter keyword: A20, IAV, PPAR, NF-κB, NLRP3 inflammasome

Fang Wang
contact affiliation	Jilin University
contact email	wf@jlu.edu.cn
lab head
Yinuo Gu
contact affiliation	Jilin University
contact email	guyn20@mails.jlu.edu.cn
dataset submitter

iProX dataset URI