PXD035477-1

PXD035477 is an original dataset announced via ProteomeXchange.

Title	Characterization of the interactome profiling of Mycoplasma DnaK in cancer cell reveals interference with key cellular pathways
Description	Chaperone proteins are redundant in nature and, to achieve their function, they bind a large repertoire of client proteins. DnaK is a bacterial chaperone protein that recognizes misfolded and aggregated proteins and drives their folding and intracellular trafficking. Some Mycoplasmas are associated with cancers, and we demonstrated that infection with a strain of Mycoplasma fermentans isolated in our lab promoted lymphoma in a mouse model. Its DnaK is expressed intracellularly in infected cells, it interacts with key proteins to hamper essential pathways related to DNA repair and p53 functions and uninfected cells can take-up extracellular DnaK.
HostingRepository	PRIDE
AnnounceDate	2022-10-12
AnnouncementXML	Submission_2022-10-12_09:48:35.917.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	NicholasSherman
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-21 03:39:55	ID requested
⏵ 1	2022-10-12 09:48:36	announced

Dataset with its publication pending

submitter keyword: proteomics, cellular pathways, Chaperone protein, DnaK protein,Mycoplasma fermentans

DavideZella
contact affiliation	Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA
contact email	DZella@ihv.umaryland.edu
lab head
NicholasSherman
contact affiliation	University of Virginia
contact email	nes3f@virginia.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD035477

PRIDE project URI

• PRIDE
  1. PXD035477
     1. Label: PRIDE project
     2. Name: Characterization of the interactome profiling of Mycoplasma DnaK in cancer cell reveals interference with key cellular pathways