PXD035422 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Data in support of Temporal changes of inflammation and endothelial dysfunction in multiple sclerosis related to the evolution of enhancing lesions on frequent brain MRI |
| Description | Blood-brain-barrier (BBB) breakdown and active inflammation by relapsing–remitting (RRMS) lesions are hallmarks of multiple sclerosis (MS). Leaky endothelial junctions causes an increased expression of circulating immune cells with associated adhesion molecules on endothelial cell membrane but also an increased production of endothelial derived extracellular microvesicles (EV). Methods: Relapsing–remitting MS (RRMS) patients with no disease-modifying treatment were monitored with weekly intervals using high-resolution 3T MRI scanning. Plasma samples from each measurement were analyzed for protein biomarkers of inflammation by quantitative proteomics, cytokines and chemokines using multiplex immunoassay. Extracellular microvesicles were characterized by an optimized endothelial stress EV Array analysis for detection of soluble secreted microvesicles. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_06:25:55.683.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Allan Stensballe |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-07-20 01:16:31 | ID requested | |
| 1 | 2024-01-26 07:12:29 | announced | |
| ⏵ 2 | 2024-10-22 06:25:56 | announced | 2024-10-22: Updated project metadata. |
Publication List
| Illes Z, J, ø, rgensen MM, B, æ, k R, Bente LM, Lauridsen JT, Hyrlov KH, Aboo C, Baumbach J, Kacprowski T, Cotton F, Guttmann CRG, Stensballe A, New Enhancing MRI Lesions Associate with IL-17, Neutrophil Degranulation and Integrin Microparticles: Multi-Omics Combined with Frequent MRI in Multiple Sclerosis. Biomedicines, 11(12):(2023) [pubmed] |
| 10.3390/biomedicines11123170; |
Keyword List
| submitter keyword: multiple sclerosis |
| proteomics |
| translational biomarker |
| blood brain barrier |
| flair |
Contact List
| Allan Stensballe |
|---|
| contact affiliation | Laboratory for translational biomarkers and digital health |
| contact email | as@hst.aau.dk |
| lab head | |
| Allan Stensballe |
|---|
| contact affiliation | Aalborg University |
| contact email | as@hst.aau.dk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035422
- Label: PRIDE project
- Name: Data in support of Temporal changes of inflammation and endothelial dysfunction in multiple sclerosis related to the evolution of enhancing lesions on frequent brain MRI
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