PXD035367-1
PXD035367 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Analysis of protein expression changes in patients with prediabetes using high-throughput proteomics |
| Description | Objective: This study aimed to explore the mechanisms of early-onset T2DM by analyzing proteomic changes at different stages of glucose metabolism. Methods: A total of 40 individuals undergoing routine physical health examinations between December 2016 and April 2017 were enrolled. Subjects were divided into four groups based on fasting blood glucose (FPG) levels: 10 cases with FPG <5.6 mmol/L (group A); 10 cases with FPG ≥5.6 mmol/L and <6.1 mmol/L (group B); 10 cases with FPG ≥6.1 mmol/L and <7.0 mmol/L (group C); and 10 cases with FPG ≥7.0 mmol/L (group D). Results of differential proteomic analysis performed by label-free quantification were compared with metabolites determined by metabolomics. Results: A total of 277 differentially expressed proteins were screened and were identified as mainly secreted proteins. Comparing group A with group B, 32 proteins were up-regulated (fold change >1.2; p <0.05) and 18 proteins were down-regulated (fold change <-1.2; p <0.05). Comparing group B with group C, 3 pro |
| HostingRepository | iProX |
| AnnounceDate | 2022-07-15 |
| AnnouncementXML | Submission_2022-07-17_19:49:12.359.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Huan Li |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-07-17 19:49:01 | ID requested | |
| ⏵ 1 | 2022-07-17 19:49:12 | announced | |
| 2 | 2023-12-06 20:15:27 | announced | 2023-12-07: Update publication. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: prediabetes，high-throughput proteomics，CD14，CSF-1R |
Contact List
| Xiaomin Xie | |
|---|---|
| contact affiliation | The First People's Hospital of Yinchuan |
| contact email | xiaominxie@inbox.lv |
| lab head | |
| Huan Li | |
| contact affiliation | The First People's Hospital of Yinchuan |
| contact email | nfmk7167@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
to receive all new ProteomeXchange dataset release announcements!
