PXD035309-1

PXD035309 is an original dataset announced via ProteomeXchange.

Title	Lysine Acetylome Profiling Reveals Diverse Functions of Acetylation in Deinococcus Radiodurans
Description	D. radiodurans is distinguished by the most radioresistant organism identified to date. Lysine acetylation is a highly conserved post-translational modification that plays an essential role in the regulation of many cellular processes and may contribute to its extraordinary radioresistance. We integrate acetyl-lysine enrichment strategy, high-resolution mass spectrometry, and bioinformatics to profile the lysine acetylated proteins for the first time. It is striking that almost half of the total annotated proteins are identified as acetylated forms, which is the largest acetylome dataset reported in D. radiodurans to date. The acetylated proteins are involved in metabolic pathways, propanoate metabolism, carbon metabolism, fatty acid metabolism, and the tricarboxylic acid cycle. The results of this study reinforce the notion that acetylation plays critical regulatory roles in diverse aspects of the cellular process, especially in DNA damage repair and metabolism. It provides insight into the roles of lysine acetylation in the robust resistance to radiation.
HostingRepository	PRIDE
AnnounceDate	2022-08-09
AnnouncementXML	Submission_2022-08-09_01:10:37.671.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yongqian Zhang
SpeciesList	scientific name: Deinococcus radiodurans R1; NCBI TaxID: 243230;
ModificationList	acetylated residue
Instrument	Q Exactive HF; ultraflex

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-13 08:24:09	ID requested
⏵ 1	2022-08-09 01:10:38	announced

Dataset with its publication pending

submitter keyword: Deinococcus radiodurans

Lysine acetylation

DNA Damage

Posttranslational modification

Yongqian Zhang
contact affiliation	Beijing Institute of Technology
contact email	zyq@bit.edu.cn
lab head
Yongqian Zhang
contact affiliation	Beijing Insititute of Technology
contact email	zyq@bit.edu.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD035309
     1. Label: PRIDE project
     2. Name: Lysine Acetylome Profiling Reveals Diverse Functions of Acetylation in Deinococcus Radiodurans