PXD035299 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nuclear protein expression profiling of IMR90 RAS cells compared to IMR90 Control cells |
| Description | One-third of all human cancers are attributable to mutations in RAS. Induction of oncogenic RAS during tumorigenesis leads to metabolic reprogramming and enhanced proliferation or senescence. These profound phenotypic changes require adaptations in gene expression, RNA processing, and protein synthesis. To investigate core drivers of this transformation, we analysed nuclear protein expression in IMR90 RAS cells and IMR90 Control cells 6 days after induction of HRASG12V. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-17 |
| AnnouncementXML | Submission_2026-02-17_03:39:44.224.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Alex Montoya |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-07-13 06:10:48 | ID requested | |
| ⏵ 1 | 2026-02-17 03:39:45 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: HRASG12V, nuclear proteins, RAS,IMR90, senescence |
Contact List
| Dr Pavel Shliaha |
|---|
| contact affiliation | Head of Proteomics and Metabolomics Facility |
| contact email | p.shliaha@lms.mrc.ac.uk |
| lab head | |
| Alex Montoya |
|---|
| contact affiliation | Medical Research Council - London Institute of Medical Sciences |
| contact email | alex.montoya@lms.mrc.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD035299 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035299
- Label: PRIDE project
- Name: Nuclear protein expression profiling of IMR90 RAS cells compared to IMR90 Control cells
