PXD035264 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Autophagy is dispensable for the maintenance of parvalbumin interneurons but required for their inhibitory neurotransmission and memory |
| Description | Previous studies have demonstrated the requirement of autophagy for neuronal survival and synaptic function, mostly focusing on projection neurons and excitatory neurotransmission. Here, we examine the effects of conditional atg5 ablation in neurons expressing parvalbumin (PV-cKO), which in the forebrain mainly represent fast-spiking inhibitory interneurons. Contrary to the prevailing view, we show that autophagy-deficient PV neurons survive throughout the brain, with the exception of the projection Purkinje neurons in the cerebellum, which rapidly degenerate. While not affecting their maintenance, autophagy deficiency leads to aberrant proteostasis of key synaptic and other proteins, culminating to reduced inhibitory neurotransmission in hippocampal PV-interneurons. Consistently, PV-cKO animals exhibit associative and recognition memory deficits. Our findings demonstrate a neuronal type-specific vulnerability to autophagy deficiency, while also identifying PV-interneurons as the cellular substrates where autophagy is required for memory formation. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-02 |
| AnnouncementXML | Submission_2026-02-01_16:58:17.947.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Patrice Waridel |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2022-07-11 14:49:29 | ID requested | |
| ⏵ 1 | 2026-02-01 16:58:18 | announced | |
Publication List
| 10.1080/15548627.2025.2597463; |
| Chalatsi T, Wosnitzka E, Kolaxi A, Fernandez LMJ, Scholler J, Batti L, Restivo L, Knott G, L, ΓΌ, thi A, Mameli M, Nikoletopoulou V, Autophagy regulates PVALB (parvalbumin) interneuron excitability and memory. Autophagy, 22(2):351-370(2026) [pubmed] |
Keyword List
| submitter keyword: autophagy,Mus musculus, neurons, Fusion |
Contact List
| Vassiliki Nikoletopoulou |
|---|
| contact affiliation | Department of Fundamental Neurosciences (DNF) University of Lausanne Rue du Bugnon 9 CH-1005 Lausanne Switzerland |
| contact email | vassiliki.nikoletopoulou@unil.ch |
| lab head | |
| Patrice Waridel |
|---|
| contact affiliation | University of Lausanne |
| contact email | patrice.waridel@unil.ch |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD035264 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035264
- Label: PRIDE project
- Name: Autophagy is dispensable for the maintenance of parvalbumin interneurons but required for their inhibitory neurotransmission and memory
