PXD035235-1

PXD035235 is an original dataset announced via ProteomeXchange.

Title	Host cell response after infection with a virulent and a non virulent Acinetobacter baumannii IC2 OXA-23 strain
Description	Acinetobacter baumannii is an emerging nosocomial pathogen that causes severe infections such as pneumonia or blood stream infections. As the incidence of multidrug-resistant A. baumannii infections in intensive care units increases, the pathogen is considered of greater clinical concern. Little is known about the molecular interaction of A. baumannii with its host yet. In order to study the host cell response upon A. baumannii infection, a complexome analysis was performed. For this, we identified a virulent ( A. baumannii 2778) and a non virulent (A. baumannii 1372) clinical isolate of genetic similarity > 95 % (both isolates from IC 2 harboring OXA 23). HUVECs were infected with each strain and enriched mitochondrial fraction was used for complexome profiling. Complexome analysis identified dramatic reduction of mitochondrial protein complexes in the strain of greater virulence.
HostingRepository	PRIDE
AnnounceDate	2023-04-10
AnnouncementXML	Submission_2023-04-10_08:24:12.434.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	IlkaWittig
SpeciesList	scientific name: Acinetobacter baumannii ACICU; NCBI TaxID: 405416; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-11 08:24:32	ID requested
⏵ 1	2023-04-10 08:24:12	announced

Dataset with its publication pending

submitter keyword: Complexome profiling,Host-pathogen interaction

StephanGöttig
contact affiliation	Institute for Medical Microbiology and Infection Control, Goethe University Frankfurt am Main, Germany
contact email	Stephan.goettig@kgu.de
lab head
IlkaWittig
contact affiliation	Functional Proteomics, Goethe University, Frankfurt am Main , Germany
contact email	wittig@med.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD035235

PRIDE project URI

• PRIDE
  1. PXD035235
     1. Label: PRIDE project
     2. Name: Host cell response after infection with a virulent and a non virulent Acinetobacter baumannii IC2 OXA-23 strain