PXD035186-1

PXD035186 is an original dataset announced via ProteomeXchange.

Title	Kinase activity profiling in breast cancer samples
Description	In this study, we measured the kinase activity profiles of 32 pre-treatment tumour biopsies of HER2-positive breast cancer patients. The aim of this study was to assess the prognostic potential of kinase activity levels in prediction of treatment success against HER2-targeted therapy combined with chemotherapy. Indeed, our system-wide kinase activity analysis, based on targeted mass spectrometry measurement of kinase activation loops, allowed us to link kinase activity to treatment response. Overall, high kinase activity in the HER2-pathway was associated with good treatment outcome. Furthermore, we found eleven kinases differentially regulated between treatment outcome groups.
HostingRepository	PanoramaPublic
AnnounceDate	2024-03-09
AnnouncementXML	Submission_2024-03-09_20:10:53.298.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Donna Olivia Debets
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Phospho; Carbamidomethyl; Oxidation; Label:13C(6)15N(2); Label:13C(6)15N(4)
Instrument	TSQ Altis

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-08 08:53:25	ID requested
⏵ 1	2024-03-09 20:10:53	announced

no publication

submitter keyword: Breast cancer, clinical, kinase activity, phosphorylation, treatment prediction

Maarten Altelaar
contact affiliation	Utrecht University
contact email	m.altelaar@uu.nl
lab head
Donna Olivia Debets
contact affiliation	Utrecht University
contact email	d.o.debets@uu.nl
dataset submitter

Panorama Public dataset URI