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PXD035186 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleKinase activity profiling in breast cancer samples
DescriptionIn this study, we measured the kinase activity profiles of 32 pre-treatment tumour biopsies of HER2-positive breast cancer patients. The aim of this study was to assess the prognostic potential of kinase activity levels in prediction of treatment success against HER2-targeted therapy combined with chemotherapy. Indeed, our system-wide kinase activity analysis, based on targeted mass spectrometry measurement of kinase activation loops, allowed us to link kinase activity to treatment response. Overall, high kinase activity in the HER2-pathway was associated with good treatment outcome. Furthermore, we found eleven kinases differentially regulated between treatment outcome groups.
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterDonna Olivia Debets
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListPhospho; Carbamidomethyl; Oxidation; Label:13C(6)15N(2); Label:13C(6)15N(4)
InstrumentTSQ Altis
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-07-08 08:53:25ID requested
12024-03-09 20:10:53announced
Publication List
no publication
Keyword List
submitter keyword: Breast cancer, clinical, kinase activity, phosphorylation, treatment prediction
Contact List
Maarten Altelaar
contact affiliationUtrecht University
contact emailm.altelaar@uu.nl
lab head
Donna Olivia Debets
contact affiliationUtrecht University
contact emaild.o.debets@uu.nl
dataset submitter
Full Dataset Link List
Panorama Public dataset URI