PXD035129-1

PXD035129 is an original dataset announced via ProteomeXchange.

Title	Proteome alterations in MLL-rearranged leukemia cells following WIN Site inhibition
Description	WIN Site inhibitors bind the WIN Site of WDR5 resulting in decreased transcription of WDR5 target genes, many of which encode components of the protein synthesis machinery. In this study, we determined proteome alterations in an MLL-rearranged leukemia cell line treated for either 24 or 72 hours with a WIN Site inhibitor. The data from these studies, along with Ribo-Seq, RNA-Seq, and CRISPR screen experiments, guided us in assembling a collection of compounds that, when combined with WIN Site inhibitor, synergistically inhibit growth of MLL-rearranged leukemia cells.
HostingRepository	PRIDE
AnnounceDate	2023-07-04
AnnouncementXML	Submission_2023-07-04_05:52:36.202.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	KristieLindsey Rose
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2022-07-06 14:43:12	ID requested
⏵ 1	2023-07-04 05:52:36	announced
2	2024-10-22 05:52:03	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: proteomics, acute myeloid leukemia, ribosome,WDR5, label-free quantification, chromatin, translation

Kristie LindseyRose
contact affiliation	Vanderbilt University Proteomics Core
contact email	kristie.rose@vanderbilt.edu
lab head
KristieLindsey Rose
contact affiliation	Vanderbilt university
contact email	kristie.rose@vanderbilt.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD035129

PRIDE project URI

• PRIDE
  1. PXD035129
     1. Label: PRIDE project
     2. Name: Proteome alterations in MLL-rearranged leukemia cells following WIN Site inhibition