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PXD035129

PXD035129 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome alterations in MLL-rearranged leukemia cells following WIN Site inhibition
DescriptionWIN Site inhibitors bind the WIN Site of WDR5 resulting in decreased transcription of WDR5 target genes, many of which encode components of the protein synthesis machinery. In this study, we determined proteome alterations in an MLL-rearranged leukemia cell line treated for either 24 or 72 hours with a WIN Site inhibitor. The data from these studies, along with Ribo-Seq, RNA-Seq, and CRISPR screen experiments, guided us in assembling a collection of compounds that, when combined with WIN Site inhibitor, synergistically inhibit growth of MLL-rearranged leukemia cells.
HostingRepositoryPRIDE
AnnounceDate2023-07-04
AnnouncementXMLSubmission_2023-07-04_05:52:36.202.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKristieLindsey Rose
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Exploris 480
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-07-06 14:43:12ID requested
12023-07-04 05:52:36announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: proteomics, acute myeloid leukemia, ribosome,WDR5, label-free quantification, chromatin, translation
Contact List
Kristie LindseyRose
contact affiliationVanderbilt University Proteomics Core
contact emailkristie.rose@vanderbilt.edu
lab head
KristieLindsey Rose
contact affiliationVanderbilt university
contact emailkristie.rose@vanderbilt.edu
dataset submitter
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Dataset FTP location
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