PXD035129 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteome alterations in MLL-rearranged leukemia cells following WIN Site inhibition |
Description | WIN Site inhibitors bind the WIN Site of WDR5 resulting in decreased transcription of WDR5 target genes, many of which encode components of the protein synthesis machinery. In this study, we determined proteome alterations in an MLL-rearranged leukemia cell line treated for either 24 or 72 hours with a WIN Site inhibitor. The data from these studies, along with Ribo-Seq, RNA-Seq, and CRISPR screen experiments, guided us in assembling a collection of compounds that, when combined with WIN Site inhibitor, synergistically inhibit growth of MLL-rearranged leukemia cells. |
HostingRepository | PRIDE |
AnnounceDate | 2023-07-04 |
AnnouncementXML | Submission_2023-07-04_05:52:36.202.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | KristieLindsey Rose |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-07-06 14:43:12 | ID requested | |
⏵ 1 | 2023-07-04 05:52:36 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: proteomics, acute myeloid leukemia, ribosome,WDR5, label-free quantification, chromatin, translation |
Contact List
Kristie LindseyRose |
contact affiliation | Vanderbilt University Proteomics Core |
contact email | kristie.rose@vanderbilt.edu |
lab head | |
KristieLindsey Rose |
contact affiliation | Vanderbilt university |
contact email | kristie.rose@vanderbilt.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD035129 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD035129
- Label: PRIDE project
- Name: Proteome alterations in MLL-rearranged leukemia cells following WIN Site inhibition