PXD035089-2
PXD035089 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Alteration of PFC proteome in MK-801 induced schizophrenia-like adolescent mice |
Description | Schizophrenia typically emerges in adolescence or early adulthood. Electrophysiological and several neurochemical changes have linked the GABA deficits to abnormal behaviors induced by NMDAR hypofunction. However, few studies have systematically investigated the molecular basis of GABA deficits, especially during adolescence. To address this issue, we transiently administrated MK-801 to mice on PND 10, which exhibited schizophrenia-relevant deficits in adolescence. Saline treated mice was served as controls. Cortical proteomics was performed on adolescent mice to investigate the proteome alteration. |
HostingRepository | iProX |
AnnounceDate | 2022-07-05 |
AnnouncementXML | Submission_2022-12-24_20:55:23.861.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ting Xue |
SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | SYNAPT G2-Si |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-07-04 20:15:29 | ID requested | |
1 | 2022-07-04 20:15:44 | announced | |
⏵ 2 | 2022-12-24 20:55:24 | announced | 2022-12-25: Update publication information. |
Publication List
Xue T, Wang X, Hu Y, Cheng Y, Li H, Shi Y, Wang L, Yin D, Cui D, Embryonic Deletion of TXNIP in GABAergic Neurons Enhanced Oxidative Stress in PV+ Interneurons in Primary Somatosensory Cortex of Aging Mice: Relevance to Schizophrenia. Brain Sci, 12(10):(2022) [pubmed] |
Keyword List
submitter keyword: PFC proteome, Schizophrenia, MK801 |
Contact List
Donghong Cui | |
---|---|
contact affiliation | Shanghai Mental Health Center |
contact email | manyucc@126.com |
lab head | |
Ting Xue | |
contact affiliation | Shanghai Mental Health Center |
contact email | xueting221314@126.com |
dataset submitter |
Full Dataset Link List
iProX dataset URI |