PXD035046-1
PXD035046 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Rapid Monocyte Recruitment Dictates the Therapeutic Efficacy of Focal Radiotherapy |
| Description | The recruitment of monocytes and their differentiation into immunosuppressive cells is associated with the negative outcome of non-conformal radiotherapy (RT). However, non-conformal RT is irrelevant in the clinic, and little is known about the role of monocytes following radiotherapy modes used in patients, such as conformal radiotherapy (CRT). Here, we investigated the acute immune infiltration post-CRT. Contrary to non-conformal RT approaches, we found that CRT induces a rapid and robust recruitment of monocytes to the tumor that minimally differentiate into tumor-associated macrophages (TAM) or dendritic cells (DC), but instead upregulate major histocompatibility complex II (MHCII) and costimulatory molecules. We establish that these large numbers of infiltrating monocytes are responsible for increasing type I interferon in the tumor microenvironment (TME), activation of CD8+ T cells and the reduction in tumor burden. Importantly, we demonstrate that rapid monocyte infiltration to the TME is hindered when RT inadvertently affects healthy tissues. Our results unravel a positive role of monocytes during clinically relevant modes of RT and demonstrate that limiting exposure of healthy tissues to radiation has a positive therapeutic effect on the overall immune response within the tumor. |
| HostingRepository | MassIVE |
| AnnounceDate | 2023-05-03 |
| AnnouncementXML | Submission_2023-05-03_08:57:24.632.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Juliana Idoyaga |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | TMTpro |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2022-06-30 07:37:20 | ID requested | |
| ⏵ 1 | 2023-05-03 08:57:25 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Radiation, Monocytes |
Contact List
| Juliana Idoyaga | |
|---|---|
| contact affiliation | Stanford University |
| contact email | jidoyaga@stanford.edu |
| lab head | |
| Juliana Idoyaga | |
| contact affiliation | Stanford University |
| contact email | jidoyaga@stanford.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000089775/ |
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