PXD034918-1

PXD034918 is an original dataset announced via ProteomeXchange.

Title	DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions
Description	DNA methylation is essential for embryonic development and implicated in the regulation of genomic imprinting. Genomic imprinting is established in the germline through parent-specific methylation of distinct cis-regulatory DNA sequences, called imprinting control regions (ICRs). Which factors bind to the opposing chromatin states at ICRs within the same nuclear environment was not systematically addressed. By using a proximity labelling approach with the methylation sensitive transcription factor ZFP57, we identified ATF7IP and other major components of the epigenetic maintenance machinery at ICRs.
HostingRepository	PRIDE
AnnounceDate	2023-03-10
AnnouncementXML	Submission_2023-03-10_13:01:27.466.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	TuncayBaubec
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	biotinylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-26 07:46:59	ID requested
⏵ 1	2023-03-10 13:01:28	announced
2	2023-11-14 08:02:37	announced	2023-11-14: Updated project metadata.

Butz S, Schmolka N, Karemaker ID, Villase, ñ, or R, Schwarz I, Domcke S, Uijttewaal ECH, Jude J, Lienert F, Krebs AR, de Wagenaar NP, Bao X, Zuber J, Elling U, Sch, ü, beler D, Baubec T, DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions. Nat Genet, 54(11):1702-1710(2022) [pubmed]

submitter keyword: Epigenetic, DNA methylation, Genomic Imprinting

TuncayBaubec
contact affiliation	Institute of Biodynamics and Biocomplexity (IBB) Department of Biology Faculty of Science Utrecht University Kruytbuilding N806 Padualaan 8, 3584 CH Utrecht The Netherlands
contact email	t.baubec@uu.nl
lab head
TuncayBaubec
contact affiliation	University of Zurich
contact email	tuncay.baubec@uzh.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD034918

PRIDE project URI

• PRIDE
  1. PXD034918
     1. Label: PRIDE project
     2. Name: DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions