PXD034901 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Acetylation of p62 regulates base excision repair through interaction with APE1 |
Description | p62, a well-known adaptor of autophagy, plays multiple functions in response to various stresses. Here, we report a function for p62 in base excision repair that is distinct from its known functions. Loss of p62 impairs BER capacity and increases the sensitivity of cancer cells to alkylating and oxidizing agents. In response to alkylative and oxidative damage, p62 is accumulated in the nucleus,acetylated by hMOF, deacetylated by SIRT7, and acetylated p62 is recruited to chromatin. The chromatin-enriched p62 directly interacts with APE1, a key enzyme of the BER pathway, and promotes its endonuclease activity, which facilitates BER and cell survival. Collectively, our findings demonstrate that p62 is a regulator of BER, and provide further rationale for targeting p62 as a cancer therapeutic strategy. |
HostingRepository | PRIDE |
AnnounceDate | 2022-07-19 |
AnnouncementXML | Submission_2022-07-18_19:17:22.008.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Meiting Li |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-06-26 07:31:20 | ID requested | |
⏵ 1 | 2022-07-18 19:17:22 | announced | |
2 | 2023-11-14 08:57:08 | announced | 2023-11-14: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Base excision repair, p62, Acetylation, hMOF, SIRT7, APE1 |
Contact List
Haiying Wang |
contact affiliation | Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China. |
contact email | wendy@bjmu.edu.cn |
lab head | |
Meiting Li |
contact affiliation | Peking University Health Science Center |
contact email | Limeiting401@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD034901
- Label: PRIDE project
- Name: Acetylation of p62 regulates base excision repair through interaction with APE1