PXD034717-1
PXD034717 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Phosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway |
Description | In this study, we found that CB inhibited ICC cell proliferation and promoted cell apoptosis. By using phosphoproteomics, we found significant changes in the proteome and phosphorylome associated with DNA damage and apoptosis in response to CB treatment. Further investigations demonstrated that CB induced ICC cell apoptosis by activating the ATM/CHK2/p53 signaling pathway and upregulating the expression of Fas, DR4 and DR5. Our results collectively indicate that CB may serve as a potential anti-cholangiocarcinoma drug |
HostingRepository | iProX |
AnnounceDate | 2022-06-20 |
AnnouncementXML | Submission_2022-06-20_04:43:40.165.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Wenbo Meng |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2022-06-20 04:43:34 | ID requested | |
⏵ 1 | 2022-06-20 04:43:40 | announced | |
2 | 2023-12-06 20:17:07 | announced | 2023-12-07: Update publication. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Phosphoproteomics |
Contact List
Wenbo Meng | |
---|---|
contact affiliation | The First Hospital of Lanzhou University, Lanzhou, Gansu, China. |
contact email | mengwb@lzu.edu.cn |
lab head | |
Wenbo Meng | |
contact affiliation | The First Hospital of Lanzhou University, Lanzhou, Gansu, China. |
contact email | mengwb@lzu.edu.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |