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PXD034711-1

PXD034711 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Aspirin-acetylated SIRT1 induces apoptosis and modulates healthy aging
Description	Aspirin or cellular acetyl-CoA could directly acetylate proteins to affect diversity functions. We identify HDACs could be the directly acetylated substrates of aspirin. The inside functional lysine of SIRT1 could be acetylated by aspirin or acetyl-CoA but not be deacetylated by active SIRT1. This irreversible acetylation of SIRT1 inhibits its activity and regulates healthy aging in C. elegans.
HostingRepository	iProX
AnnounceDate	2022-06-20
AnnouncementXML	Submission_2022-06-20_01:33:55.353.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhen Wu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	acetylated residue; acetate labeling reagent (N-term) (heavy form, +3amu); S-carboxamidoethyl-L-cysteine; methionine oxidation with neutral loss of 64 Da
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-20 01:33:43	ID requested
⏵ 1	2022-06-20 01:33:55	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: Aspirin, SIRT1, Acetylome

Contact List

Wei Yu
contact affiliation	State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University
contact email	yuw@fudan.edu.cn
lab head
Zhen Wu
contact affiliation	Fudan University
contact email	wuz16@fudan.edu.cn
dataset submitter

Full Dataset Link List

iProX dataset URI