PXD034525-2

PXD034525 is an original dataset announced via ProteomeXchange.

Title	A Peptide-Centric Quantitative Proteomics Dataset for the Phenotypic Assessment of Alzheimer’s Disease
Description	Alzheimer’s disease (AD) is a looming public health disaster with limited interventions. Desperately needed progress in therapeutic development rests on more detailed understanding of molecular pathogenesis. The vast majority of existing data for AD pathogenesis in humans is from standard neuropathologic assessments, e.g., neuritic plaques and neurofibrillary tangles or biochemical measurement of a limited number of analytes directly related to neuropathologic features, e.g., amyloid-β peptides and hyperphosphorylated tau. Standard neuropathologic evaluation is highly valuable as the only tool that provides comprehensive assessment of diseases that afflict an individual brain, but it also is severely limited in its ability to investigate molecular pathogenesis. Advances in mass spectrometry-based proteomics techniques provide robust quantitative measures, allowing for insight into the protein phenotype in brains with AD neuropathology. Careful selection of individuals in multiple research cohorts enabled us, for the first time, to investigate the full spectrum of molecular signatures specific to autosomal dominant AD dementia (ADD), sporadic ADD with minimal comorbidities, individuals without dementia who had high histopathologic burden of AD, and cognitively normal individuals with no or minimal AD histopathologic burden.
HostingRepository	PanoramaPublic
AnnounceDate	2023-04-18
AnnouncementXML	Submission_2023-04-18_09:04:21.937.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Gennifer Merrihew
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4)
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-15 01:17:42	ID requested
1	2022-11-22 22:42:24	announced
⏵ 2	2023-04-18 09:04:22	announced	: Added PubMed Id

Merrihew GE, Park J, Plubell D, Searle BC, Keene CD, Larson EB, Bateman R, Perrin RJ, Chhatwal JP, Farlow MR, McLean CA, Ghetti B, Newell KL, Frosch MP, Montine TJ, MacCoss MJ, A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer's disease. Sci Data, 10(1):206(2023) [pubmed]

submitter keyword: Quantitative Proteomics, DIA Mass Spectrometry, Alzheimer’s disease, peptide-centric, human brain tissue

Michael MacCoss
contact affiliation	University of Washington
contact email	maccoss@uw.edu
lab head
Gennifer Merrihew
contact affiliation	University of Washington
contact email	genn@uw.edu
dataset submitter

Panorama Public dataset URI