PXD034484-1

PXD034484 is an original dataset announced via ProteomeXchange.

Title	Region-Resolved Proteomic Map of the Human Brain: Functional Interconnections and Neurological Implications
Description	While progress has been made in transcriptomic profiling of the human brain, functional characterization of brain regions and their interactions based on regional protein expression remains limited. Here, we construct a proteomic map from thirteen anatomical brain regions of eight cadaver donors to elucidate region-specific protein expression patterns and their implications for brain function. The results underscore the interconnectivity of the four cerebral lobes, suggesting facilitated information integration through large-scale neural networks. We propose a three-module framework (Cortical Integration Module [frontal lobe, temporal lobe, parietal lobe, occipital lobe], Limbic-Relay Network [amygdaloid nucleus, hippocampus, thalamus/hypothalamus], and Midline Regulatory Axis [thalamus/hypothalamus, corpus callosum, ventricles, optic chiasm]), and provide molecular evidence supporting the potential involvement of the Midline Regulatory Axis, brainstem, and cerebellum in higher-order cognitive functions. The Midline Regulatory Axis may play a critical but underexplored role in neurodevelopment, inter-regional signaling, and structural homeostasis, potentially relying on efficient synaptic function, energy metabolism, and extracellular matrix integrity. This analysis may enhance understanding of brain physiology and highlight the need to integrate proteomic and transcriptomic approaches in studying brain function and neurological disorders.
HostingRepository	iProX
AnnounceDate	2025-12-08
AnnouncementXML	Submission_2025-12-08_01:25:11.590.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jia Zhou
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-12 00:41:50	ID requested
⏵ 1	2025-12-08 01:25:12	announced

Dataset with its publication pending

submitter keyword: Proteomics, Spatial proteomics, Mass Spectrometry, Brain, Homeostasis, Function, Neural connectivity, Cerebral lobes, Brain Stem, Ventricle

Ling Leng
contact affiliation	Peking Union Medical College Hospital
contact email	lengling@pumch.cn
lab head
Jia Zhou
contact affiliation	Peking Union Medical College Hospital
contact email	zhou18@student.pumc.edu.cn
dataset submitter

iProX dataset URI