PXD034440-2

PXD034440 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Chemical degradation of BTK/TEC as a novel approach to inhibit platelet function.
Description	Determination of the effect of the generic tyrosine kinase degrader TL12-186, and the BTK degraders DD-04-15 and DD-03-171 on human platelet protein content and function.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:56:49.568.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Justin Trory
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	carbamoylated residue
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2022-06-09 15:13:50	ID requested
1	2023-03-02 02:17:08	announced
⏵ 2	2023-11-14 08:56:49	announced	2023-11-14: Updated project metadata.

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

ProteomeXchange project tag: Cardiovascular (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project
submitter keyword: Human, Platelet, Targeted protein degradation, BTK, PROTAC, TEC

ProteomeXchange project tag: Cardiovascular (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: Human, Platelet, Targeted protein degradation, BTK, PROTAC, TEC

Contact List

Ingeborg Hers
contact affiliation	School of Physiology, Pharmacology and Neuroscience Faculty of Life sciences University of Bristol
contact email	i.hers@bristol.ac.uk
lab head
Justin Trory
contact affiliation	Bristol univeristy Phd Student
contact email	justin.trory@bristol.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD034440
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD034440

PRIDE project URI

Repository Record List

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