PXD034213-1

PXD034213 is an original dataset announced via ProteomeXchange.

Title	PHACTR1, a coronary artery disease risk gene, drives endothelial dysfunction
Description	Recent genome-wide association studies have identified PHACTR1 as a critical risk gene associated with polyvascular diseases. However, it remains elusive how PHACTR1 is involved in endothelial dysfunction. Here, we show that PHACTR1 triggers endothelial inflammation by activating NF-κB and disrupts Nitric oxide production by inhibiting Akt/eNOS activation to induce endothelial diastolic disorder. Whereas, Atorvastatin particularly plays an inhibitory effect on PHACTR1 gene expression in a dose-dependent manner among PHACTR family in endothelial cells. PHACTR1 may interact with PP1 with coupling with heat shock protein 8 (HSPA8) to dephosphorylate Akt or eNOS.
HostingRepository	PRIDE
AnnounceDate	2022-08-16
AnnouncementXML	Submission_2022-08-16_05:00:20.959.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ma Xiaoxuan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-30 11:33:34	ID requested
⏵ 1	2022-08-16 05:00:21	announced

Dataset with its publication pending

submitter keyword: Endothelial dysfunction

Inflammation

PHACTR1

Nitric oxide

Innate immunity

Coronary artery disease

Suowen Xu
contact affiliation	Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
contact email	sxu1984@ustc.edu.cn
lab head
Ma Xiaoxuan
contact affiliation	Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
contact email	2712306722@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/08/PXD034213

PRIDE project URI

• PRIDE
  1. PXD034213
     1. Label: PRIDE project
     2. Name: PHACTR1, a coronary artery disease risk gene, drives endothelial dysfunction