PXD034147-1

PXD034147 is an original dataset announced via ProteomeXchange.

Title	Serum peptidomic screening identified circulating peptide biomarkers
Description	Background: Reliable biomarkers are needed to improve preeclampsia (PE) prediction accuracy. With the investigational tool of peptidomics, we aimed to identify and validate potential serum peptide biomarkers in cohorts suspected for PE development in middle or late pregnancy. Methods: Totally 195 serum samples were prospectively collected from pregnant women with PE-related syndromes who were followed up for PE development until delivery. Serum peptidomic analysis was performed in the discovery cohort of 115 samples using matrix-assisted laser desorption ionization-time of flight coupled with Linear Trap Quadropole Orbitrap mass spectrometry. The candidate biomarkers were further validated using an in-house developed liquid chromatography tandem mass spectrometry (LC-MS/MS) method in an independent validation cohort of 80 serum samples.
HostingRepository	iProX
AnnounceDate	2022-05-26
AnnouncementXML	Submission_2022-05-26_01:53:23.335.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chunbo li
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-26 01:53:11	ID requested
⏵ 1	2022-05-26 01:53:23	announced
2	2023-01-28 18:17:54	announced	2023-01-29: Update publication information.

Dataset with its publication pending

submitter keyword: Serum peptidomic, preeclampsia

Zheng Cao
contact affiliation	Beijing Gynecologics and Obstetrical Hospital
contact email	zhengcao2011@hotmail.com
lab head
Chunbo li
contact affiliation	Sciex China
contact email	chunbo.li@sciex.com
dataset submitter

iProX dataset URI