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PXD034076-1

PXD034076 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleBioactive insulin-loaded electrospun wound dressings for localized drug delivery and stimulation of protein expression associated with wound healing
DescriptionEffective therapy of wounds is difficult, especially for chronic, non-healing wounds, and novel therapeutics are urgently needed. This challenge can be addressed with bioactive wound dressings providing a microenvironment and facilitating cell proliferation and migration, ideally incorporating actives which initiate and/or progress effective healing upon release. In this context, electrospun scaffolds loaded with growth factors emerged as promising wound dressings due to their biocompatibility, similarity to the extracellular matrix and potential for controlled drug release. In this study, electrospun core-shell fibers were designed composed of a combination of polycaprolactone and polyethylene oxide. Insulin, a proteohormon with growth factor characteristics, was successfully incorporated into the core and was released in a controlled manner. The fibers exhibited favorable mechanical properties and a surface guiding cell migration for wound closure in combination with a high uptake capacity for wound exudate. Biocompatibility and significant wound healing effects were shown in interaction studies with human skin cells. As a new approach, analysis of the wound proteome in treated ex vivo human skin wounds clearly demonstrated a remarkable increase in wound healing biomarkers. Based on these findings, insulin-loaded electrospun wound dressings bear a high potential as effective wound healing therapeutics overcoming current challenges in the clinics.
HostingRepositoryPRIDE
AnnounceDate2022-12-19
AnnouncementXMLSubmission_2022-12-19_04:08:46.041.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJasminSchäfer
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-05-25 02:18:46ID requested
12022-12-19 04:08:46announced
22023-11-14 08:56:32announced2023-11-14: Updated project metadata.
Publication List
Keyword List
submitter keyword: coaxial electrospinning,bioactive wound dressings, proteomics, biomolecules, wound healing, core-shell fibers, human in vitro wound models, drug delivery
Contact List
ChristianMünch
contact affiliationInstitute of Biochemistry II University Hospital Frankfurt Goethe University Germany
contact emailch.muench@em.uni-frankfurt.de
lab head
JasminSchäfer
contact affiliationMünch lab, Institute of Biochemistry II, Goethe University Frankfurt
contact emailja.schaefer@em.uni-frankfurt.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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