PXD034029-1

PXD034029 is an original dataset announced via ProteomeXchange.

Title	Global and tissue-specific aging effects on murine proteomes
Description	Maintenance of protein homeostasis degrades with age, contributing to aging-related decline and disease. Previous studies have primarily surveyed transcriptional aging changes. To define the effects of age directly at the protein level, we perform discovery-based proteomics in 10 tissues from 20 C57BL/6J mice, representing both sexes at adult and late midlife ages (8 and 18 months). Consistent with previous studies, age-related changes in protein abundance often have no corresponding transcriptional change. Aging results in increases in immune proteins across all tissues, consistent with a global pattern of immune infiltration with age. Our protein-centric data reveal tissue-specific aging changes with functional consequences, including altered endoplasmic reticulum and protein trafficking in the spleen. We further observe changes in the stoichiometry of protein complexes with important roles in protein homeostasis, including the CCT/TriC complex and large ribosomal subunit. These data provide a foundation for understanding how proteins contribute to systemic aging across tissues.
HostingRepository	PRIDE
AnnounceDate	2023-07-06
AnnouncementXML	Submission_2023-07-06_11:21:00.250.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	DevinSchweppe
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-23 03:52:31	ID requested
⏵ 1	2023-07-06 11:21:00	announced
2	2023-11-14 07:03:28	announced	2023-11-14: Updated project metadata.
3	2024-10-22 05:52:24	announced	2024-10-22: Updated project metadata.

submitter keyword: mouse, TMT, multiplexed proteomics, tissue proteomics, real-time search, aging

DevinSchweppe
contact affiliation	Department of Genome Sciences, University of Washington
contact email	dkschwep@uw.edu
lab head
DevinSchweppe
contact affiliation	University of Washingt, Department of Genome Sciences
contact email	dkschwep@uw.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD034029

PRIDE project URI

• PRIDE
  1. PXD034029
     1. Label: PRIDE project
     2. Name: Global and tissue-specific aging effects on murine proteomes