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PXD034014 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe small RNA Teg41 is a pleiotropic regulator of virulence in Staphylococcus aureus
DescriptionStaphylococcus aureus is Gram-positive commensal bacteria that can also cause human disease ranging from mild, self-resolving skin infections to life-threatening conditions like endocarditis, osteomyelitis, and septicemia. Previously we demonstrated a role for the S. aureus sRNA, Teg41 in regulating production of the alpha Phenol Soluble Modulin toxins (αPSMs). In this study, we further characterize the regulatory role of Teg41. RNAseq analysis shows Teg41 influences the abundance of not just the αPSM transcript, but a variety of other transcripts as well compared to wild type S. aureus. Proteomic analysis confirms that eliminating Teg41 from the cell influences both the cytoplasmic and secreted protein profile of S. aureus. Finally, we observe that the Teg41Δ3′ strain is more severely attenuated in two murine infection models than a ∆αPSM strain, indicating that Teg41 regulation reaches beyond the αPSMs. Overall, we show that Teg41 is a unique pleiotropic sRNA in S. aureus that influences several key cellular processes.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRonan Carroll
SpeciesList scientific name: Staphylococcus aureus; NCBI TaxID: 1280;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02022-05-20 10:43:26ID requested
12022-10-03 06:13:44announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Staphylococcus aureus Teg41 PSM spa
Contact List
Ronan Carroll
contact affiliationDepartment of Biological Sciences, Ohio University
contact emailcarrolr3@ohio.edu
lab head
Ronan Carroll
contact affiliationOhio University
contact emailcarrolr3@ohio.edu
dataset submitter
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Dataset FTP location
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