PXD034010-1

PXD034010 is an original dataset announced via ProteomeXchange.

Title	Posttranslational splicing modifications as a key mechanism in cytarabine resistance in AML
Description	Despite the approval of several drugs for AML, cytarabine is still widely used as a therapeutic approach. However, most patients show resistance and only 10% of them overcome the disease. Using high-throughput screening analysis, we show that phosphorylation levels of SR proteins were elevated during cytarabine resistance. Moreover, phosphorylation of SR proteins at diagnosis was different between responder and non-responder patients, pointing to their utility to predict response. These changes correlated with altered transcriptomic profiles of SR protein target genes.
HostingRepository	PRIDE
AnnounceDate	2023-07-04
AnnouncementXML	Submission_2023-07-04_04:53:36.440.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	EduardoZarzuela
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	impact

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-20 10:24:54	ID requested
⏵ 1	2023-07-04 04:53:36	announced
2	2024-10-22 05:52:00	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: AML, cytarabine, phosphorylation

Javier MuñozPeralta
contact affiliation	CNIO
contact email	javier.munozperalta@osakidetza.eus
lab head
EduardoZarzuela
contact affiliation	Centro Nacional de Investigaciones Oncológicas
contact email	eduzarfer@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD034010

PRIDE project URI

• PRIDE
  1. PXD034010
     1. Label: PRIDE project
     2. Name: Posttranslational splicing modifications as a key mechanism in cytarabine resistance in AML