PXD033956-1

PXD033956 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomics of BYL719 (alpelisib)-Resistant T47D Human Breast Cancer Cell Line
Description	The PI3Kalpha-specific inhibitor Alpelisib (BYL719) has been approved for the treatment of metastatic ER+/HER2- breast cancer patients in combination with Fulvestrant. After initial response, patients develop drug resistance and disease relapses. In order to identify signalling pathways contributing to the acquired resistance to BYL719 in breast cancer, we generated BYL719-resistant T47D cells and used them together with the parental cells to perform label-free quantitative phosphoproteomics.
HostingRepository	PRIDE
AnnounceDate	2023-12-05
AnnouncementXML	Submission_2023-12-05_06:04:32.281.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kelvin Yip
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-18 04:28:35	ID requested
⏵ 1	2023-12-05 06:04:32	announced
2	2024-02-07 01:34:06	announced	2024-02-07: Updated project metadata.
3	2024-10-22 06:16:53	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Targeted therapies, human breast cancer, PI3K, BYL719, phosphoproteomics, alpelisib

Antonella Papa
contact affiliation	Cancer Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia.
contact email	antonella.papa@monash.edu
lab head
Kelvin Yip
contact affiliation	Monash University
contact email	kelvin.yip@monash.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/12/PXD033956

PRIDE project URI

• PRIDE
  1. PXD033956
     1. Label: PRIDE project
     2. Name: Phosphoproteomics of BYL719 (alpelisib)-Resistant T47D Human Breast Cancer Cell Line