PXD033935-1

PXD033935 is an original dataset announced via ProteomeXchange.

Title	Natural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors.
Description	Atypical teratoid/rhabdoid tumors (AT/RT) are highly aggressive CNS-tumors of infancy and early childhood. Hallmark is the surprisingly simple genomics with a truncating mutation in the SMARCB1 gene as the oncogenic driver. Nevertheless, AT/RTs are infiltrated by immune cells and even clonally expanded T-cells. However, it is unclear, what T-cells might recognize on AT/RT cells. Here, we report a comprehensive analysis of naturally presented HLA-class-I and class-II ligands on n=23 AT/RTs. MS-based analysis of the HLA-ligandome revealed 55 class-I and 139 class-II peptides from tumor-associated proteins.
HostingRepository	PRIDE
AnnounceDate	2022-05-31
AnnouncementXML	Submission_2022-05-31_02:38:46.086.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ana Marcu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	LTQ Orbitrap XL

Revision	Datetime	Status	ChangeLog Entry
0	2022-05-17 08:13:45	ID requested
⏵ 1	2022-05-31 02:38:47	announced

Marcu A, Schlosser A, Keupp A, Trautwein N, Johann P, W, ö, lfl M, Lager J, Monoranu CM, Walz JS, Henkel LM, Krau, ß J, Ebinger M, Schuhmann M, Thomale UW, Pietsch T, Klinker E, Schlegel PG, Oyen F, Reisner Y, Rammensee HG, Eyrich M, Natural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors. J Immunother Cancer, 9(10):(2021) [pubmed]

submitter keyword: Human, primary AT/RT tumors, HLA-I and HLA-II

Prof. Dr. med. Matthias EyrichChildren’s Hospital, University Medical Center Würzburg, Germany
contact affiliation	Children’s Hospital, University Medical Center Würzburg, Germany
contact email	Eyrich_M@ukw.de
lab head
Ana Marcu
contact affiliation	University of Tübingen, Interfaculty Institute for Cell Biology, Department of Immunology
contact email	anamarcu.pe@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD033935

PRIDE project URI

• PRIDE
  1. PXD033935
     1. Label: PRIDE project
     2. Name: Natural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors.