PXD033922 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Protein interaction partners of long non-coding RNA NUDT6 in human aortic smooth muscle cells |
Description | The long non-coding RNA NUDT6 was found to be deregulated in abdominal aortic aneurysm (AAA) with higher expression in diseased human tissue specimens versus control aortic tissue. Apart from the already well-studied DNA: RNA interaction as a natural antisense transcript to Fibroblast Growth Factor 2 (FGF2), we were interested in identifying protein interaction partners to unravel further involvement in the pathogenesis and progression of abdominal aortic aneurysm. Therefore, we performed a RNA pulldown experiment using biotinylated NUDT6 and control RNA in human aortic smooth muscle cell lysate to identify further interaction partners. |
HostingRepository | PRIDE |
AnnounceDate | 2024-01-26 |
AnnouncementXML | Submission_2024-01-26_06:22:23.651.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ilka Wittig |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2022-05-16 08:25:26 | ID requested | |
⏵ 1 | 2024-01-26 06:22:24 | announced | |
Publication List
10.1016/j.ymthe.2023.04.020; |
Winter H, Winski G, Busch A, Chernogubova E, Fasolo F, Wu Z, B, ä, cklund A, Khomtchouk BB, Van Booven DJ, Sachs N, Eckstein HH, Wittig I, Boon RA, Jin H, Maegdefessel L, Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression. Mol Ther, 31(6):1775-1790(2023) [pubmed] |
Keyword List
submitter keyword: abdominal aortic aneurysm, vascular disease, long non-coding RNAs,LC-MSMS, RNA/Protein Interaction |
Contact List
Lars Mägdefessel |
contact affiliation | Klinikum rechts der Isar der TU München, Munich, Germany |
contact email | lars.maegdefessel@tum.de |
lab head | |
Ilka Wittig |
contact affiliation | Functional Proteomics, Goethe University, Frankfurt am Main , Germany |
contact email | wittig@med.uni-frankfurt.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD033922
- Label: PRIDE project
- Name: Protein interaction partners of long non-coding RNA NUDT6 in human aortic smooth muscle cells